Human c1-esterase inhibitor
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94 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hereditary angioedemas | D054179 | EFO_0004131 | — | 5 | 19 | 20 | 5 | 14 | 57 |
| Angioedema | D000799 | EFO_0005532 | T78.3 | 3 | 13 | 15 | 2 | 12 | 39 |
| Hereditary angioedema types i and ii | D056829 | — | — | 2 | 4 | 2 | 1 | 1 | 9 |
| Inborn genetic diseases | D030342 | EFO_0000508 | — | — | 4 | 3 | 1 | — | 6 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | 1 | — | 1 |
| Primary immunodeficiency diseases | D000081207 | — | — | — | — | — | 1 | — | 1 |
| Common variable immunodeficiency | D017074 | EFO_0000367 | D83 | — | — | — | 1 | — | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | 1 | — | 1 |
| Rare diseases | D035583 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | — | 1 | 2 | — | 1 | 4 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | 2 | — | 1 | 3 |
| Wounds and injuries | D014947 | — | T14.8 | — | 1 | 1 | — | — | 2 |
| Endotoxemia | D019446 | — | — | — | — | 1 | — | 1 | 2 |
| Multiple organ failure | D009102 | EFO_1001373 | — | — | — | 1 | — | 1 | 2 |
| Innate immunity | D007113 | — | — | — | — | 1 | — | — | 1 |
| Immune system diseases | D007154 | — | D89.9 | — | 1 | 1 | — | — | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | 1 | 1 | — | — | 1 |
| Edema | D004487 | — | R60.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | 4 | — | — | — | 4 |
| Reperfusion injury | D015427 | — | — | 1 | 3 | — | — | — | 3 |
| Renal insufficiency | D051437 | — | N19 | 3 | 1 | — | — | — | 3 |
| Kidney transplantation | D016030 | — | — | 1 | 3 | — | — | — | 3 |
| Acute kidney injury | D058186 | — | N17 | — | 3 | — | — | — | 3 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | 2 | — | — | — | 2 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | 2 | — | — | — | 2 |
| Head and neck neoplasms | D006258 | — | — | 1 | 2 | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 2 | — | — | — | 2 |
| Melanoma | D008545 | — | — | 1 | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuromyelitis optica | D009471 | EFO_0004256 | G36.0 | 1 | — | — | — | — | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | — | — | — | — | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | — | — | — | — | 1 |
| Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | 1 | — | — | — | — | 1 |
| Ischemia | D007511 | EFO_0000556 | — | 1 | — | — | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | — | — | — | — | 1 |
| Cerebral infarction | D002544 | — | I63 | 1 | — | — | — | — | 1 |
| Brain infarction | D020520 | EFO_0004277 | I63 | 1 | — | — | — | — | 1 |
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Immunologic tests | D007159 | — | — | — | — | — | — | 1 | 1 |
| Graft vs host disease | D006086 | — | D89.81 | — | — | — | — | 1 | 1 |
| Systemic mastocytosis | D034721 | — | C96.21 | — | — | — | — | 1 | 1 |
| Urticaria | D014581 | EFO_0005531 | L50 | — | — | — | — | 1 | 1 |
| Mastocytosis | D008415 | — | D47.09 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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16,313 adverse events reported
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